Research Overview


If you're a prospective student, or you're interested in making a tax-free donation towards funding these projects please contact purnima@purnima.net. Current Projects Immune function in Colorectal Cancer: Bowel cancers frequently utilise immune evasion to enable further tumour growth and metastasis. Tumours contain large numbers of specific active immune cells that appear to be non-functional. Tumour cells secrete proteins that may be modifying the function of the immune cells that are invading the tumour. Cells within excised colorectal cancers are tested for immune function and protein expression, as well as bacterial colonisation to determine the effects these factors may have on modulating the tumour environment. We are currently recruiting patients with colorectal cancer who will undergo bowel resection in Canberra. If you wish to take part in this study or find out more information, contact purnima@purnima.net. Murine models for Colorectal Cancer: Animal models of bowel cancer can vastly aid in our understanding of the disease and its treatment. Most models however, involve implanting tumours in mice under the skin or in the peritoneum, which are not subject to the same immune and bacterial environment. We are developing an orthotopic murine model for colorectal cancer using mouse endoscopy and endomicroscopy to study the bacterial environment and the gut immune environment and the effects of these on tumour growth and development. Future Projects The effect of the mucosal immune environment on hepatitis B virus persistence and transmission: Viral transmission in infancy appears to rely on an underdeveloped immune system to chronically infect the neonate. We will study the nutrional and gut immune factors that influence HBV transmission in infancy.
Research Overview
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